Table 1 Comparisons between the methods used to make the orthotopic tumour model.
From: Endoscopic non-ablative fractional laser therapy in an orthotopic colon tumour model
Methods | Success rate (%) (# of successful attempts /total used mice) | Last follow-up (days) | Advantages | Disadvantages |
|---|---|---|---|---|
Intra-luminal seeding with laparotomy | 20.0 (3/15) | 45 | Simultaneous introduction of a large number of cancer cells | Laparotomy is necessary; Complicated surgical procedure |
Intra-colonic wall injection with laparotomy | 75.0 (6/8) | 21 | Relatively simple procedure | Laparotomy is necessary; High rate of failure of the intracolonic injections |
Endoscopic implantation | 92.3 (12/13) | 10 | Minimally invasive; Relatively faster tumour growth | Endoscopic tools are necessary; High rate of failure of the intracolonic injections |
