Figure 2
From: 2-Phenylquinazolinones as dual-activity tankyrase-kinase inhibitors
Crystal structures showing the binding mode of (a) 2 (PDB code 4BUY)18, (b) (+)-8 and (c) 9 to TNKS2 catalytic domain. Black dashed lines represent hydrogen bonds and red spheres represent water molecules. Sigma A weighted 2Fo – Fc electron density map around the ligands is contoured at 1.5 σ.
