Figure 5
From: 2-Phenylquinazolinones as dual-activity tankyrase-kinase inhibitors
Crystal structure showing the binding mode of (a) 29, (b) 30, (c) 31, (d) 32, (e) 33, (f) 34 to TNKS2 catalytic domain. Black dashed lines represent hydrogen bonds and red spheres represent water molecules. Sigma A weighted 2Fo – Fc electron density map around the ligands is contoured at 1.5 σ. Ile1075 was left out for clarity.
