Figure 7
From: 2-Phenylquinazolinones as dual-activity tankyrase-kinase inhibitors
Structural representation showing the binding site of the inhibitors. (a) 42 and (b) 41 were docked into the active site of CDK9 (PDB code 3TNH). (c) Superposed structures of CDK9 (PDB code 3TNH, blue) and Akt (PDB code 4EKK, magenta)41,42 including compound 42. (d) Crystal structure of CK2 complexed with apigenin (PDB code 4DGM, green)43. Black dashed lines represent hydrogen bonds and red spheres represent water molecules.
