Table 1 Comparison of baseline characteristics in patients vs. controls group.

From: MRI of the cervical spinal cord predicts respiratory dysfunction in ALS

 

Patients (n = 40)

Controls (n = 21)

p-value

Characteristics

Age

56.18 (10.50)

55.48 (13.43)

0.82

Sex (men/women)

33/7

15/6

0.34

Bilateral pre-central and central (motor) cortex

Volume

0.56 (0.08)

0.67 (0.11)

<0.0001

R2

14.73 (1.54)

15.17 (1.69)

0.60

NAA

1.41 (0.19)

1.56 (0.18)

0.005

Bilateral PLIC

FA

0.61 (0.05)

0.62 (0.09)

0.61

MD + , median [IQR]

7.21 [7.03 ‒ 7.53]

7.18 [6.75 ‒ 7.32]

0.32

Medulla oblongata

Volume

0.20 (0.03)

0.24 (0.04)

<0.0001

R2

16.85 (2.54)

17.06 (2.44)

0.76

FA

0.33 (0.06)

0.35 (0.14)

0.56

MD + , median [IQR]

8.31 [7.87 ‒ 9.50]

9.02 [7.64 ‒ 13.64]

0.50

Cervical spinal cord

Volume, median [IQR]

2437 [2117 ‒ 2736]

2689 [2354 ‒ 2999]

0.060

R2, median [IQR]

38.13 [35.01 ‒ 46.13]

37.60 [36.67 ‒ 40.44]

0.71

  1. Data are expressed as the mean (SD), unless otherwise indicated. Volume (as a percentage of the intracranial volume and in mm3 for the spinal cord); R2* mean values (1/T2*) (in s−1) Abbreviations: PLIC: posterior limb of internal capsule; FA: fractional anisotropy; MD: mean diffusivity; NAA: N-acetyl aspartate; IQR: interquartile range; SD: standard deviation. +In units × 10000.