Table 3 Multivariable Cox Proportional Hazards Model of Factors Associated with Mortality.

From: A retrospective clinical comparison of daptomycin vs daptomycin and a beta-lactam antibiotic for treating vancomycin-resistant Enterococcus faecium bloodstream infections

 

Adjusted Model 1a

 

Adjusted Model 2c,d

Hazard ratio (95% CI)

P

Hazard ratio (95% CI)

P

Steroid use

2.86 (1.42–5.79)

0.003

Steroid use

3.28 (1.64–6.57)

0.001

Pitt bacteremia score

1.17 (1.05–1.30)

0.004

Pitt bacteremia score

1.17 (1.05–1.30)

0.005

Platelet count (×104/μL)

0.96 (0.92–0 0.99)

0.02

Platelet count (×104/μL)

0.96 (0.92–0.99)

0.02

Treatment regimens

DAP dose (mg/kg)

0.74 (0.58–0.93)

0.01

DAP dose ≥9 mg/kg with BLA

Reference

 

DAP + BLA

0.90 (0.41–1.96)

0.79b

DAP dose <9 mg/kg without BLA

5.16 (1.34–19.89)

0.02

   

DAP dose <9 mg/kg with BLA

5.39 (1.62–17.93)

0.006

DAP dose ≥9 mg/kg without BLA

19.01 (2.96–121.95)

0.002

  1. Abbreviations: BLA, beta-lactam antibiotic; CI, confidence interval; DAP, daptomycin.
  2. aTest of proportional-hazards assumption: P = 0.92.
  3. bDAP + BLA was forced as an independent variable in the final adjusted model 1.
  4. cTest of proportional-hazards assumption: P = 0.73.
  5. dInteractions between daptomycin dose and beta-lactam combinations were considered in the final adjusted model 2.
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