Figure 6

Preprocessing of the T₁ Map Acquired with 7 T MP2RAGE. Preprocessing included (A) skull stripping and within-subject alignment of the T₁ maps, (B) automated delineation of hippocampal subfields, and (C) estimation of median T₁ relaxation time for each hippocampal subfield. Note that within-subject alignment of time points T1, T2, and T3 is not shown as it resembled the procedure for time point T0, respectively. MR images refer to an exemplary sagittal view of a single subject for illustrative purposes. FLIRT = FMRIB’s Linear Image Registration Tool, MP2RAGE = magnetization-prepared two rapid acquisition gradient echoes, MR = Magnetic Resonance, STAPLE = simultaneous truth and performance level estimation, SyN = symmetric normalization method, TP = time point.