Table 1 Clinico-pathological features of 817 patients diagnosed with classical Hodgkin lymphoma.

Parameter	N	%	1954–1979 (n = 128)	%	1980–1999 (n = 320)	%	2000–2008 (n = 369)	%	P
EBV status
Positive	459	56	111	87	179	56	169	46	<0.0001*
Negative	358	44	17	13	141	44	200	54
Age (years)
<15	155	19	26	20	76	24	53	14	0.02
15–44	483	59	73	57	185	58	225	61
≥45	179	22	29	23	59	18	91	25
Gender
Male	506	62	103	80	189	59	214	58	0.0001*
Female	311	38	25	20	131	41	155	42
Histology
Nodular sclerosis	572	70	79	62	222	69	271	73	0.005
Mixed celularity	185	23	33	26	78	24	74	20
Lymphocyte rich	17	2	1	1	5	2	11	3
Lymphocyte depletion	18	2	7	5	8	3	3	1
Unclassifiable	25	3	8	6	7	2	10	3
Ann Arbor Staging
I-II	283	35	26	20	104	33	152	41	0.002*‡
III-IV	356	44	69	54	121	38	167	45
NA	178	21	33	26	95	30	50	14

*Cochran-Armitage test for trend. ^‡Analysis included only Ann-Arbor stages I-II and III-IV. NA: Data not available.
The Pearson chi-squared test was used to assess for the presence of an association between variables with more than two categories (age and gender) and time periods.

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