Figure 6 | Scientific Reports

Figure 6

From: DUSP5 is methylated in CIMP-high colorectal cancer but is not a major regulator of intestinal cell proliferation and tumorigenesis

Figure 6

Impact of DUSP5 overexpression on ERK signaling in the mouse intestine. (A) Expression of human DUSP5 protein in the intestinal epithelium detected by blotting for the Myc-tag. (B) Expression of human DUSP5 mRNA specifically in the intestinal epithelium of transgenic mice. (C) Body weight of wild-type and Vil-DUSP5 Tg mice determined over time. Effects of DUSP5 overexpression on the (D) intensity and pattern of pERK1/2 staining and (E) expression ERK signalling-regulated genes in the intestinal epithelium. Three mice of each genotype were analysed.

Back to article page