Table 3 Cytotoxic activities (IC50) of C13-methylene modified derivatives.

From: Diversity Modification and Structure-Activity Relationships of Two Natural Products 1β-hydroxy Alantolactone and Ivangustin as Potent Cytotoxic Agents

No.

IC50a (μM)

PC-3

HepG2

1j

>40

>40

1k

>40

>40

1l

>40

>40

1m

>40

>40

1n

>40

>40

1o

>40

>40

1p

>40

>40

1q

>40

>40

1r

>50

>50

1s

>50

>50

  1. aCells were treated with compounds for 72 h. All data (mean ± SD) are the average of three or four independent experiments in triplicate.
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