Table 2 Cox proportional hazards regression to identify predictors of overall and disease free survival in HCC patients treated by resection.

From: The lymphocyte-to-monocyte ratio is a superior predictor of overall survival compared to established biomarkers in HCC patients undergoing liver resection

 

Overall Survival

Disease–free Survival

Univariable

Multivariable

Univariable

Multivariable

HR

95% CI

P

HR

95% CI

P

HR

95% CI

P

HR

95% CI

P

Male

0.919

0.685–1.234

0.576

   

1.027

0.756–1.396

0.863

   

Age (≥60 years)

1.003

0.752–1.337

0.984

   

0.918

0.690–1.221

0.557

   

LMR <4.01

1.763

1.421–2.187

<0.001

1.454

1.142–1.851

0.002

1.60

1.296–1.975

<0.001

1.266

1.007–1.593

0.044

Positive HBsAg

1.198

0.876–1.638

0.258

   

1.224

0.898–1.667

0.201

   

Liver cirrhosi

1.192

0.895–1.586

0.229

   

0.983

0.751–1.286

0.899

   

AFP ≥ 400 ng/mL

1.451

1.173–1.795

0.001

1.174

0.940–1.466

0.157

1.580

1.282–1.948

<0.001

1.389

1.121–1.722

0.003

BCLC stage B or C

1.852

1.590–2.158

<0.001

1.279

1.056–1.550

0.012

1.768

1.518–2.060

<0.001

0.926

0.681–1.259

0.624

Edmonson grade III–IV

1.324

0.789–2.089

0.203

   

1.245

0.823–1.765

0.324

   

Child-Pugh class B

1.350

0.877–2.076

0.172

   

1.219

0.730–2.036

0.448

   

Tumor number

2.075

1.673–2.574

<0.001

1.542

1.221–1.946

<0.001

2.109

1.700–2.617

<0.001

1.941

1.527–2.466

<0.001

Tumor size ≥ 5 cm

2.214

1.729–2.835

<0.001

1.544

1.160–2.056

0.003

1.850

1.465–2.335

<0.001

1.533

1.140–2.063

0.005

Tumor capsule

2.164

1.721–2.720

<0.001

1.812

1.421–2.310

<0.001

1.639

1.319–2.037

<0.001

1.371

1.095–1.716

0.003

Albumin ≥ 35 g/L

1.401

0.980–1.962

0.053

   

0.957

0.655–1.400

0.822

   

Platelet count ≥  100 × 109/L

0.991

0.729–1.348

0.956

   

1.344

0.964–1.874

0.081

   

AST ≥ 80U/L

1.445

1.096–1.905

0.009

1.156

0.868–1.539

0.321

1.278

0.965–1.693

0.088

   

ALT ≥ 80U/L

0.861

0.610–1.216

0.395

   

0.942

0.678–1.309

0.721

   

Total bilirubin ≥  17.1 μmol/L

1.134

0.893–1.439

0.304

   

1.042

0.826–1.315

0.729

   

NLR ≥ 2.78

1.762

1.405–2.210

<0.001

1.284

0.989–1.668

0.061

1.797

1.436–2.250

<0.001

1.506

1.165–1.947

0.002

PLR ≥ 99.5

1.299

1.054–1.601

0.014

0.877

0.692–1.112

0.279

1.338

1.089–1.645

0.006

0.990

0.788–1.243

0.930

  1. Abbreviations: HBsAg, hepatitis B surface antigen; AFP, alpha-fetoprotein; BCLC, Barcelona Clinic Liver Cancer; AST, aspartate aminotransferase; ALT, alanine aminotransferase; HCC, Hepatocellular Carcinoma; HR = hazard ratio; CI = confience interval.
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