Figure 2 | Scientific Reports

Figure 2

From: Small-molecule flunarizine increases SMN protein in nuclear Cajal bodies and motor function in a mouse model of spinal muscular atrophy

Figure 2

Treatment with flunarizine improves the phenotype of SMA mice. (A) Kaplan-Meier survival curves for vehicle (V)- (n = 19) and flunarizine (Flz)-treated SMA mice (n = 12); (B) Body weight of vehicle- (n = 67) and flunarizine-treated controls (n = 68) and vehicle- (n = 19) and flunarizine-treated SMA mice (n = 12); (C) antigravity hanging performance of vehicle- (n = 35) and flunarizine-treated controls (n = 40) and vehicle- (n = 18) and flunarizine-treated SMA mice (n = 10); (D) Number of crossings during 5 min for vehicle- (n = 35) and flunarizine-treated controls (n = 40) and vehicle- (n = 19) and flunarizine-treated SMA mice (n = 10). The drug is administrated at a daily dose of 0.5 mg/kg. Mean ± SEM.

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