Figure 5 | Scientific Reports

Figure 5

From: Electrophilic fatty acid nitroalkenes regulate Nrf2 and NF-κB signaling:A medicinal chemistry investigation of structure-function relationships

Figure 5

Time course of GCLM, HO1 and NQO1 steady-state RNA levels following treatment of RAW264.7 cells with electrophilic compounds. qPCR analysis showing relative mRNA levels following the treatment with 10 μM NCE-1, -2, -8, -10, OA-NO2, DMF and 100 nM CDDO-Im for 2, 4, 8 and 16 hr in RAW cells. The values in the bar graph represent mean ± SEM for at least three independent experiments (n = 3–12). Compared to the vehicle (DMSO) treatment group at each time point, statistical significance is indicated by: (a) p < 0.05; (b) p < 0.01 and (c) p < 0.001.

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