Figure 1

Effect of Na+ and HCO3− replacement on currents mediated by WT or Q913X mutants in Xenopus oocytes. (A) Representative current-voltage (I–V) relationship from a H2O-injected oocyte as it was sequentially exposed to ‘Na (0 HCO3)’, ‘Na, HCO3’, and ‘(0 Na) HCO3’ solutions. (B–H) Equivalent data from oocytes expressing WT, Q913R, Q913C, Q913E, Q913K, Q913L, or Q913S.