Figure 3
From: TDP-43 self-interaction is modulated by redox-active compounds Auranofin, Chelerythrine and Riluzole
TDP-43 self-interaction under treatment with compounds riluzole, auranofin and chelerythrine. Interaction of constructs pFN33_TDP-43 and pFN35_TDP-43 under treatment with compounds riluzole (A + B), auranofin (C + D) and chelerythrine (E + F) measured with established NanoBit complementation reporter assay. Results described in % of untreated reference for each compound concentration (1.6–62.5 µM), initially in TDP-43 NanoBit luminescence in relation to cell proliferation WST-8 assay (A,C + E) and as TDP-43 NanoBit luminescence compared to NanoLuc control NanoBit luminescence (B,D + F) for each treatment, Mean ± SD, Mann-Whitney-U-Test, *p < 0.05, **p < 0.01, n = 6.
