Table 1 Effects of selected pharmacologically active compounds from LOPAC®1280 library on TDP-43 self-interaction. Interaction of constructs pFN33_TDP-43 and pFN35_TDP-43 under treatment with compounds of the LOPAC®1280 library, a collection of inhibitors, receptor ligands, pharma-developed tools, and approved drugs covering most signaling pathways and all major drug target classes. Data have been referred to N2a cells transfected with Nluc construct as control. Compounds, which changed the TDP-43 self-interaction to 70% [after%/pre%] or lower have been considered as inhibitors and compounds, which increased the interaction to 120% [after%/pre%] or higher have been considered as stimulators. Chosen compounds for further investigations are written in italic.

From: TDP-43 self-interaction is modulated by redox-active compounds Auranofin, Chelerythrine and Riluzole

TDP-43 [after%/pre%]	Name	Class	Action	Description
Inhibition
30	(±)-AMT hydrochloride	Nitric oxide	Inhibitor	Nitric oxide synthase inhibitor
38	GABA	GABA	Agonist	Endogenous neurotransmitter
39	Sanguinarine chloride	Ion Pump	Inhibitor	Inhibitor of Mg²⁺ and Na + /K + -ATPase
61	I-OMe-Tyrphostin AG 538	Phosphorylation	Inhibitor	Insulin growth factor 1 (IGF-1) receptor protein tyrosine kinase inhibitor
63	*Auranofin*	*Phosphorylation*	*Inhibitor*	*Inhibitor of selenoenzyme thioredoxin reductase (TrxR)*
63	Ruthenium red	Ion Pump	Inhibitor	Inhibitor of mitochondrial Ca²⁺ uniporter
64	*Chelerythrine chloride*	*Phosphorylation*	*Inhibitor*	*PKC inhibitor*
64	p-Aminoclonidine hydrochloride	Adrenoceptor	Agonist	Alpha2 Adrenoceptor agonist
65	L-allylglyciner	Biochemistry	Inhibitor	Glutamic acid decarboxylase inhibitor
66	1-Aminocyclopropanecarboxylic acid hydrochloride	Glutamate	Agonist	NMDA glutamate receptor agonist acting at the glycine site
67	Fluvoxamine maleate	Antidepressant	Inhibitor	Selective serotonin reuptake inhibitor
69	*Oxotremorine sesquifumarate salt*	*Cholinergic*	*Agonist*	*Muscarinic acetylcholine receptor agonist with preference for the M2 receptor*
70	S-Nitrosoglutathione	Nitric Oxide	Donor	Nitric oxide donor
70	9-Amino-1,2–3,4-tetrahydroacridine hydrochloride	Cholinergic	Inhibitor	Cholinesterase inhibitor
70	THIP hydrochloride	GABA	Agonist	GABA-A receptor agonist
82	*Riluzole*	*Glutamate*	*Antagonist*	*Glutamate release inhibitor*
Stimulation
120	VER-3323 hemifumarate salt	Serotonin	Agonist	5-HT2C/5-HT2B serotonin receptor agonist
125	Vancomycin hydrochloride from Streptomyces orientalis	Antibiotic	-	Amphoteric glycopeptide antibiotic
126	Ritodrine hydrochloride	Adrenoceptor	Agonist	Beta2-Adrenoceptor agonist
126	CGP-7930	GABA	Modulator	Positive allosteric modulator of GABA-B receptors
126	R( + )-Butylindazone	Ion Pump	Inhibitor	[K + , Cl-]-cotransport inhibitor
127	GR-89696 fumarate	Opioid	Agonist	Kappa Opioid receptor agonist
128	Cefsulodin sodium salt hydrate	Antibiotic	-	Third generation cephalosporin antibiotic
131	S15535	Serotonin	Agonist	Partial 5-HT1A receptor agonist
141	Indirubin-3’-oxime	Phosphorylation	Inhibitor	Cyclin-dependent kinase inhibitor
146	*Suramin sodium salt*	*P2 Receptor*	*Antagonist*	*P2X and P2Y receptor antagonist*
150	*Reactive Blue 2*	*P2 Receptor*	*Antagonist*	*P2Y receptor antagonist*
164	N-Bromoacetamide	Na⁺ Channel	Modulator	Chemical modifier
230	1-Amino-1-cyclohexanecarboxylic acid hydrochloride	Neurotransmission	Substrate	Synthetic amino acid that crosses the blood-brain barrier by the Large Neutral Amino Acid carrier system

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