Figure 2
From: 2-Methoxyestradiol protects against pressure overload-induced left ventricular hypertrophy
Effect of 2 ME on AAC-mediated induction of fibrotic and apoptotic markers. Sham and AAC rats were treated with 2 ME (5 mg/kg/day) in the mini osmotic pump. Thereafter, (A) the mRNA level of pro III, TGFβ-I, p53 and BAX were quantified using real time-PCR. (B) Fibrotic areas were determined using Trichrome’s stain (intense blue staining), quantified and expressed as % of fibrotic area. The experiment was replicated twice and the values represent mean ± SEM (n = 6). +P < 0.05 compared to control. *P < 0.05 compared to AAC.
