Table 2 Hemodynamic parameters in rats.

From: 2-Methoxyestradiol protects against pressure overload-induced left ventricular hypertrophy

 

Control

AAC

2 ME

AAC + 2 ME

BW (baseline)

200 ± 8

195 ± 6

190 + 10

189 ± 17

BW(after 5 weeks)

504 ± 19

508 ± 10

310 + 32+

358 ± 7+*

LV-Mass (mg)

1172 ± 52

1820 ± 160+

1137 + 235

1073 ± 55*

LVPWd (mm)

2.6 ± 0.1

3.73 ± 0.22+

2.6 ± 0.21

2.8 ± 0.1*

LVPWs (mm)

1.8 ± 0.06

2.6 ± 0.12+

1.8 ± 0.22

1.9 ± 0.17*

IVSd (mm)

1.8 ± 0.02

2.57 ± 0.12+

1.89 ± 0.18

1.9 ± 0.06*

IVSs (mm)

2.5 ± 0.1

3.44 ± 0.19+

2.64 ± 0.22

2.7 ± 0.1*

Heart Rate (bpm)

336 ± 17

371 ± 23

321 ± 31

316 ± 24

% EF

73 ± 2.9

77.4 ± 4.3

75.7 ± 2.8

78 ± 2.5

% FS

46.3 ± 1.5

43.3 ± 1.2

38.8 ± 4.4

44.8 ± 2.3

TEI

0.6 ± 0.04

0.75 ± 0.02

0.66 ± 0.08

0.72 ± 0.03

ME/A (ratio)

1.26 ± 0.15

1.23 ± 0.11

1.1 ± 0.08

1.3 ± 0.07

E/E′ (mm/sec)

25.4 ± 1.4

21 ± 3.1

25.7 ± 8.5

20.6 ± 1.9

A′/E′ (mm/sec)

1.2 ± 0.07

1.08 ± 0.12

1.16 ± 0.24

1.1 ± 0.15

E′/A′ (mm/sec)

0.8 ± 0.06

0.98 ± 0.11

0.9 ± 0.21

0.96 ± 0.11

S (mm/s)

45.5 ± 2.5

53 ± 1.9+

43 ± 1.7

44 ± 3.2*

PG (mmHG)

3.4 ± 0.3

5.8 ± 0.4+

4.4 ± 0.3

2.9 ± 0.3*

  1. The experiment was replicated twice and the values represent mean ± SEM (n = 6). +P < 0.05 compared to control. *P < 0.05 compared to AAC. BW, body weight, LV mass, left ventricular mass; LVPWs, left ventricular posterior wall, systole; LVPWd, left ventricular posterior wall, diastole; IVSs, intraventricular septum, systole; IVSd, intraventricular septum, diastole; Heart rate; EF, ejection fraction; FS, fractional shortening; TEI, Tei index = (isovolumic relaxation time + isovolumic contraction time)/ ejection time; E, A, wave velocity; E′, A′, tissue doppler wave; S, sytolic tissue movement PG, Pressure Gradient.
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