Figure 4 | Scientific Reports

Figure 4

From: Genome-scale analysis of Methicillin-resistant Staphylococcus aureus USA300 reveals a tradeoff between pathogenesis and drug resistance

Figure 4

Three different groups of differentially expressed genes (DEGs) and hierarchical clustering of differentially expressed virulence and antibiotic-resistance genes. (A) Three large gene groups were determined from 730 DEGs according to their expression in response to antibiotic treatments. Group I, II, and III include 9, 174, and 547 genes, respectively. Group I genes responded to all three antibiotics treated. Group II genes responded two of the three treatments. Group III genes responded uniquely to treatment. (B) 71 genes related to antibiotics resistance or virulence were differentially expressed. They were further clustered into 10 clusters according to their expression patterns. Heatmap indicates Log2 fold-change of expression levels compared to control condition. (C) 8 genes include agrBDCA in cluster 1. (D) Another 8 genes include mecA, blaI, and blaR in cluster 2. Two clusters were negatively responded against antibiotics (L: Linezolid/control, N: nafcillin/control, V: vancomycin/control).

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