Figure 5 | Scientific Reports

Figure 5

From: Genome-scale analysis of Methicillin-resistant Staphylococcus aureus USA300 reveals a tradeoff between pathogenesis and drug resistance

Figure 5

Structure of Agr locus and proposed regulatory network established by the Agr and Mec/Bla systems. (A) According to pathway enrichment analysis, genes composing glycolysis, arginine biosynthesis, and TCA cycle were enriched in up-regulated DEGs. (B) Meanwhile, pentose phosphate (PP) pathway, amino acid and nitrogen metabolisms were enriched in down-regulated DEGs. (C) MalR, CcpA, and Fnr binding motifs were predicted from the pathways. (D) Proposed regulatory network by Agr and Mec/Bla system. Molecular mechanism of Agr induction by linezolid is unknown. MecA is proposed to inhibit the Agr system by potential binding on Agr locus. AgrA induces its downstream virulence determinants, while inhibiting expression of metabolic enzymes possibly with CcpA and ArcR. Linezolid possibly induces the expression of arginine biosynthesis pathway by MalR. This induction seems to override Agr mediated repression of arginine biosynthesis62.

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