Figure 4

Overview of results. On the left, the resulting 3D figures of both the ascending and thoraco-abdominal aorta are shown (control mouse J3). The side panels show a portion of the pre-processed phase-contrast images (axial view). Panels (a) and (c) show a detailed portion of these images, clearly showing the individual elastic lamellae (L1-L8 for the ascending part, L1-L5 for the thoraco-abdominal part). Panels (b) and (d) show the 4 quadrants (L: left, R: right, Ci: inner curvature, Co: outer curvature, D: dorsal, V: ventral) for ascending and thoraco-abdominal portion of the aorta. On the right side, the relationship between the size of ruptures (logarithmic scale of mask volume, x-axis) and the affected medial layers (y-axis) is shown. The ruptures are grouped according to treatment in panel (f and g) (control (day 0) = dark blue, day 3 = yellow, day 7 = green, day 14 = red) and according to quadrant in panels (f and h) (Ci = blue, Co = yellow, dorsal = blue, ventral = yellow, left = green, right = red).