Table 1 Clinicopathological variables and expression of miR-301a in the study cohort.

From: Elevated miR-301a expression indicates a poor prognosis for breast cancer patients

Variables

Patient Number(%)

miR-301a expression

Pa Value

 

Negative N (%)

Positive N (%)

Total

380

239(62.9)

141(37.1)

 

Age(years)

380

51.0 ± 9.9

52.7 ± 9.8

0.914

Menopausal status

   

0.014

  Pre

193(50.8)

133(35.0)

60(15.8)

 

  Post

187(49.2)

106(27.9)

81(21.3)

 

TNM stage

   

0.079

  I

108(28.4)

63(16.6)

45(11.8)

 

  II

190(50.0)

130(34.2)

60(15.8)

 

  III

82(21.6)

46(12.1)

36(9.5)

 

Grade

   

0.189

  1 or 2

284(74.7)

184(48.4)

100(26.3)

 

  3

96(25.3)

55(14.5)

41(10.8)

 

Tumour size

   

0.081

  ≤2 cm

179(47.1)

112(29.5)

67(17.6)

 

  >2, ≤5 cm

183(48.2)

120(31.6)

63(16.6)

 

  >5 cm

18(4.7)

7(1.8)

11(2.9)

 

Lymph node status

   

0.950

  Negative

211(55.5)

133(35.0)

78(20.5)

 

  Positive

169(44.5)

99(26.1)

63(16.6)

 

ER status

   

0.169

  Negative

209(55.0)

125(32.9)

84(22.1)

 

  Positive

171(45.0)

114(30.0)

57(15.0)

 

PR status

   

0.063

  Negative

247(65.0)

147(38.7)

100(26.3)

 

  Positive

133(35.0)

92(24.2)

41(10.8)

 

HER-2 status

   

0.911

  Negative

217(57.1)

137(36.1)

80(21.1)

 

  Positive

163(42.9)

102(26.8)

61(16.1)

 

Molecular subtypeb

   

0.159

  Luminal like

176(46.3)

119(31.3)

57(15.0)

 

HER-2 overexpression

74(19.5)

46(12.1)

28(7.4)

 

  Triple negative

130(34.2)

74(19.5)

56(14.7)

 
  1. ER, estrogen receptor; PR, progesterone receptor; HER-2, human epidermal growth factor receptor 2.
  2. aBased on Pearson χ2 test, Fisher’s exact test was used when needed.
  3. bDefinition of molecular subtypes: luminal like (ER and/or PR positive), HER-2 overexpression (ER and PR negative, HER-2 positive), and triple negative (ER negative, PR negative and HER-2 negative).