Table 2 Univariate and multivariate analysis of factors for disease-free survival (DFS).
From: Elevated miR-301a expression indicates a poor prognosis for breast cancer patients
| Â | Univariate analysis | Multivariate analysis | ||
|---|---|---|---|---|
HR (95% CI) | P value | HR (95% CI) | P value | |
Years | 1.009 (0.987–1.032) | 0.408 |  |  |
Menopausal status | ||||
 Pre | 1 |  |  |  |
 Post | 0.675 (0.437–1.043) | 0.675 |  |  |
Grade | ||||
 1 or 2 | 1 |  |  |  |
 3 | 1.201 (0.954–1.511) | 0.119 |  |  |
Tumour size | ||||
 ≤2 cm | 1 |  | 1 |  |
 >2, ≤5 cm | 0.404 (0.180–0.908) | 0.028 | 0.608 (0.266–1.391) | 0.239 |
 >5 cm | 0.465 (0.208–1.041) | 0.063 | 0.671 (0.294–1.528) | 0.342 |
Lymph node status | ||||
 Negative | 1 |  | 1 |  |
 Positive | 0.540 (0.350–0.833) | 0.005 | 0.462 (0.295–0.725) | 0.001 |
TNM stage | ||||
 I | 1 |  |  |  |
 II | 0.370 (0.203–0.675) | 0.001 |  |  |
 III | 0.500 (0.304–0.821) | 0.006 |  |  |
ER status | ||||
 Negative | 1 |  |  |  |
 Positive | 1.348 (0.868–2.092) | 1.184 |  |  |
PR status | ||||
 Negative | 1 |  |  |  |
 Positive | 1.571 (0.965–2.559) | 0.069 |  |  |
HER-2 status | ||||
 Negative | 1 |  |  |  |
 Positive | 1.463 (0.924–2.316) | 0.105 |  |  |
Molecular subtype | ||||
 Luminal like | 1 |  | 1 |  |
 HER-2 overexpression | 0.614 (0.387–0.977) | 0.039 | 0.606 (0.375–0.981) | 0.042 |
 Triple negative | 0.498 (0.255–0.975) | 0.042 | 0.437 (0.222–0.860) | 0.017 |
MiR-301a | ||||
 Negative | 1 |  | 1 |  |
 Positive | 0.193 (0.118–0.314) | 0.000 | 0.193 (0.118–0.316) | 0.000 |
