Table 3 Univariate and multivariate analysis of factors for overall survival (OS).
From: Elevated miR-301a expression indicates a poor prognosis for breast cancer patients
| Â | Univariate analysis | Multivariate analysis | ||
|---|---|---|---|---|
HR (95% CI) | P value | HR (95% CI) | P value | |
Years | 1.039 (1.008–1.070) | 0.014 | 1.035 (0.994–1.077) | 0.095 |
Menopausal status | ||||
  Pre | 1 |  | 1 |  |
  Post | 0.474 (0.247–0.907) | 0.024 | 0.965 (0.406–2.298) | 0.937 |
Grade | ||||
  1 or 2 | 1 |  | 1 |  |
  3 | 0.425 (0.228–0.793) | 0.007 | 0.433 (0.212–0.884) | 0.022 |
Tumour size | ||||
  ≤2 cm | 1 |  | 1 |  |
  >2, ≤5 cm | 0.176 (0.068–0.455) | 0.000 | 0.279 (0.100–0.775) | 0.014 |
  > 5 cm | 0.237 (0.094–0.596) | 0.002 | 0.366 (0.133–1.004) | 0.051 |
Lymph node status | ||||
  Negative | 1 |  | 1 |  |
  Positive | 0.295 (0.150–0.581) | 0.000 | 0.254 (0.124–0.521) | 0.000 |
TNM stage | ||||
  I | 1 |  |  |  |
  II | 0.143 (0.058–0.353) | 0.000 |  |  |
  III | 0.158 (0.077–0.324) | 0.000 |  |  |
ER status | ||||
  Negative | 1 |  |  |  |
  Positive | 1.269 (0.674–2.389) | 0.460 |  |  |
PR status | ||||
  Negative | 1 |  |  |  |
  Positive | 1.916 (0.912–4.025) | 0.086 |  |  |
HER-2 status | ||||
  Negative | 1 |  |  |  |
  Positive | 2.391 (1.138–5.023) | 0.021 |  |  |
Molecular subtype | ||||
  Luminal like | 1 |  | 1 |  |
HER-2 overexpression | 0.507 (0.268–0.959) | 0.037 | 0.709 (0.331–1.517) | 0.375 |
  Triple negative | 0.078 (0.010–0.575) | 0.012 | 0.061 (0.008–0.458) | 0.007 |
MiR-301a | ||||
  Negative | 1 |  | 1 |  |
  Positive | 0.148 (0.068–0.322) | 0.000 | 0.162 (0.073–0.361) | 0.000 |
