Table 2 Anion transmembrane transport facilitated by 1a-d and prodigiosin.

From: Small molecule anionophores promote transmembrane anion permeation matching CFTR activity

Compound

NO3−/Cl− (a)

HCO3−/Cl− (b)

Initial quenching rate(c) (s−1)

EC50 (nM)

Hill’s coefficient

EC50 (nM)

Hill’s coefficient

1a

24

1.39

1911

0.94

0.009

1b

30

1.27

2609

0.72

0.008

1c

18

1.17

1617

0.65

0.020

1d

50

1.43

42783

0.63

0.007

prodigiosin

2

1.13

58

0.91

0.079

  1. aLUV loaded with 489 mM NaCl dispersed in 489 mM NaNO3 (5 mM phosphate buffer, pH 7.2). bLUV loaded with 451 mM NaCl dispersed in 150 mM Na2SO4 (20 mM phosphate buffer, pH 7.2) upon addition of a NaHCO3 pulse to make the external bicarbonate concentration 40 mM. cLUV loaded with 102.2 mM NaNO3 dispersed in 102.2 mM NaNO3 (20 mM phosphate buffer, pH 7.2) upon addition of a NaCl pulse to make the external chloride concentration 10 mM.
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