Table 1 The top 50 significantly up-regulated annotated genes during pregnancy, ranked by adjusted P-value, displaying best BLAST hit HUGO Gene Symbol, log2 ratios, and FDR‐adjusted p‐values, along with mean expression values per stage.
Gene symbol | Gene name | Mean pregnant expression | Mean non-pregnant expression | log2 Fold Change | Adjusted P-value | Putative Function |
|---|---|---|---|---|---|---|
GUCY2C | Guanylate Cyclase 2C | 110.2 | 0.1 | 9.7 | 1.12E-38 | Transmembrane receptor |
SDR42E2 | Short Chain Dehydrogenase/Reductase Family 42E, Member 2 | 437.1 | 0.3 | 9.0 | 2.40E-25 | Oxidoreductase activity |
PLA2G10 | Phospholipase A2 Group X | 133.1 | 3.1 | 5.5 | 2.32E-20 | Lipid hydrolysis |
MOCS2 | Molybdenum Cofactor Synthesis 2 | 2174.4 | 22.0 | 7.3 | 8.60E-19 | Biosynthesis |
MIR639 | MicroRNA 639 | 22.9 | 2.8 | 3.7 | 9.73E-18 | microRNA, regulatory |
TECR | Trans-2,3-Enoyl-CoA Reductase | 22.9 | 2.8 | 3.7 | 9.73E-18 | Fatty acid synthesis |
PLA2G3 | Phospholipase A2 Group III | 1.6 | 0.1 | 4.7 | 4.87E-16 | Lipid hydrolysis |
APOL6 | apolipoprotein L6 | 151.1 | 16.1 | 3.2 | 1.36E-14 | Lipid movement |
S100P | S100 Calcium Binding Protein P | 268.3 | 0.2 | 7.9 | 5.86E-14 | Regulation of cellular processes |
STC1 | stanniocalcin 1 | 3962.9 | 39.4 | 6.2 | 7.96E-14 | Calcium and phosphate transport |
GGT1 | Gamma-Glutamyltransferase 1 | 73.4 | 2.3 | 4.9 | 1.88E-12 | Metabolism |
RDH16 | Retinol Dehydrogenase 16 (All-Trans) | 42.0 | 0.7 | 5.6 | 8.51E-12 | Metabolism |
LRRC31 | Leucine Rich Repeat Containing 31 | 35.1 | 1.2 | 5.2 | 8.51E-12 | Unknown |
SLC2A12 | Solute Carrier Family 2 Member 12 | 82.8 | 3.4 | 4.2 | 9.84E-12 | Glucose transport |
AKR1D1 | Aldo-Keto Reductase Family 1 Member D1 | 190.3 | 0.3 | 7.1 | 1.45E-11 | Steroid hormone reduction |
EHF | ETS Homologous Factor | 179.1 | 14.0 | 3.9 | 1.83E-11 | Epithelial cell differentiation |
FZD5 | Frizzled Class Receptor 5 | 5.9 | 0.5 | 3.6 | 4.97E-11 | Wnt signalling |
FGFR1 | fibroblast growth factor receptor 1 | 141.4 | 28.4 | 2.6 | 1.03E-10 | Cell differentiation |
IDO1 | Indoleamine 2,3-Dioxygenase 1 | 158.9 | 3.5 | 5.2 | 1.14E-10 | Protection of the fetus from maternal immune rejection |
CCDC129 | Coiled-Coil Domain Containing 129 | 1.9 | 0.0 | 6.1 | 2.06E-10 | Receptor binding |
BCO1 | Beta-Carotene Oxygenase 1 | 4.0 | 0.1 | 5.8 | 4.18E-10 | Metabolism of beta-carotene to vitamin A |
FOXN4 | Forkhead Box N4 | 370.7 | 23.2 | 4.1 | 5.76E-10 | Transcriptional regulation |
LRRC26 | Leucine Rich Repeat Containing 26 | 370.7 | 23.2 | 4.1 | 5.76E-10 | Regulation of potassium channels |
GRIN1 | glutamate ionotropic receptor NMDA type subunit 1 | 370.7 | 23.2 | 4.1 | 5.76E-10 | Ion channel |
HSD3B7 | Hydroxy-Delta-5-Steroid Dehydrogenase, 3 Beta- And Steroid Delta-Isomerase 7 | 2298.1 | 39.5 | 4.9 | 7.01E-10 | Bile synthesis from cholesterol; Part of enzymatic system biosynthesising steroids |
CYP27A1 | Cytochrome P450 Family 27 Subfamily A Member 1 | 295.7 | 46.8 | 2.9 | 1.51E-09 | Metabolism and biosynthesis |
ATP13A3 | ATPase 13A3 | 125.9 | 33.4 | 2.2 | 2.34E-09 | Cation transport across membranes |
MFSD4A | Major Facilitator Superfamily Domain Containing 4A | 12.3 | 0.2 | 5.5 | 2.93E-09 | Transmembrane transport |
CARNS1 | Carnosine Synthase 1 | 15.8 | 0.7 | 4.9 | 7.66E-09 | Metabolism |
ZNF750 | Zinc Finger Protein 750 | 2.6 | 0.0 | 6.0 | 9.63E-09 | Transcription factor mediating cell differentiation |
CCDC28A | Coiled-Coil Domain Containing 28A | 49.3 | 10.9 | 2.5 | 1.07E-08 | Protein binding |
IL22RA1 | interleukin 22 receptor subunit alpha 1 | 127.5 | 14.6 | 3.3 | 1.38E-08 | Class II cytokine receptor in innate immune response |
TRAT1 | T Cell Receptor Associated Transmembrane Adaptor 1 | 3.3 | 0.5 | 3.0 | 1.94E-08 | T-cell receptor stabilisation |
LY9 | Lymphocyte Antigen 9 | 2.6 | 0.1 | 4.5 | 2.89E-08 | Modulation of immune cell activity (innate and adaptive) |
SEC62 | SEC62 homolog, preprotein translocation factor | 223.0 | 39.3 | 2.8 | 3.18E-08 | Protein transport through ER |
ADPGK | ADP Dependent Glucokinase | 50.7 | 20.3 | 1.6 | 4.01E-08 | Glycolysis |
BPI | Bactericidal/Permeability-Increasing Protein | 7973.0 | 8.2 | 6.3 | 9.98E-08 | Antimicrobial (gram-negative organisms) |
DIP2B | Disco Interacting Protein 2 Homolog B | 12.4 | 5.5 | 1.6 | 1.02E-07 | Transcriptional regulation |
LETM2 | Leucine Zipper And EF-Hand Containing Transmembrane Protein 2 | 12.4 | 5.5 | 1.6 | 1.02E-07 | Ribosome binding |
SLC27A2 | solute carrier family 27 member 2 | 180.1 | 1.6 | 5.5 | 1.40E-07 | Fatty acid transport |
SC5D | Sterol-C5-Desaturase | 294.8 | 13.7 | 4.3 | 1.91E-07 | Cholesterol biosynthesis |
SLC35D2 | solute carrier family 35 (UDP-GlcNAc/UDP-glucose transporter), member D2 | 155.8 | 8.6 | 4.1 | 2.09E-07 | Nucleoside sugar transport |
TMEM213 | Transmembrane Protein 213 | 301.1 | 3.2 | 5.5 | 2.32E-07 | Membrane component |
SLC35C1 | Solute carrier family 35 member C1 | 63.8 | 7.5 | 3.3 | 2.52E-07 | Nucleoside sugar transport |
SLC16A6 | Solute carrier family 16 member 6 | 92.4 | 2.5 | 5.3 | 2.52E-07 | Lactic acid/ketone |
MICALCL | MICAL C-Terminal Like | 5.3 | 0.6 | 3.4 | 2.81E-07 | Signal transduction |
ALG12 | ALG12, Alpha-1,6-Mannosyltransferase | 52.8 | 20.1 | 1.9 | 2.81E-07 | Protein glycosylation |
SLCO4A1 | solute carrier organic anion transporter family member 4A1 | 37.6 | 3.7 | 3.4 | 3.11E-07 | Bicarbonate transport |
HDC | Histidine Decarboxylase | 102.7 | 0.4 | 5.9 | 4.33E-07 | Histamine production |
SH2D1B | SH2 Domain Containing 1B | 1.9 | 0.2 | 3.3 | 4.35E-07 | Signal transduction in immune cells |
