Table 2 The top 50 significantly down-regulated annotated genes during pregnancy, ranked by adjusted P-value, displaying best BLAST hit HUGO Gene Symbol, log2 ratios, and FDR‐adjusted p‐values, along with mean expression values per stage.
Gene Symbol | Gene name | Mean pregnant expression | Mean non-pregnant expression | log2 Fold Change | Adjusted P-value | Putative Function |
|---|---|---|---|---|---|---|
MUC5AC | Mucin 5AC, Oligomeric Mucus/Gel-Forming | 0.1 | 58.6 | −8.3 | 4.57E-38 | Extracellular matrix |
COL7A1 | collagen type VII alpha 1 chain | 0.1 | 2.6 | −4.8 | 2.66E-18 | Anchoring of basement membrane |
CBX2 | Chromobox 2 | 1.5 | 13.6 | −2.8 | 1.35E-15 | Transcriptional repression |
PGBD1 | PiggyBac Transposable Element Derived 1 | 2.9 | 25.8 | −2.7 | 1.93E-15 | Unknown |
IGHV4-28 | Immunoglobulin Heavy Variable 4-28 | 0.7 | 99.0 | −6.2 | 3.13E-15 | Antigen recognition |
CNTN2 | contactin 2 | 0.0 | 3.0 | −5.7 | 2.23E-13 | Cell adhesion |
SLCO2A1 | solute carrier organic anion transporter family member 2A1 | 2.2 | 32.2 | −3.4 | 4.70E-13 | Prostaglandin release |
SHF | Src Homology 2 Domain Containing F | 0.9 | 9.4 | −2.9 | 1.23E-12 | Regulation of apoptosis |
PTGFR | Prostaglandin F Receptor | 0.1 | 7.5 | −5.2 | 1.63E-12 | Receptor for prostaglandin F2-alpha; uterine contraction |
ADGRB2 | adhesion G protein-coupled receptor B2 | 0.1 | 5.2 | −4.3 | 3.23E-12 | Inhibition of angiogenesis |
CD200 | CD200 Molecule | 10.8 | 152.6 | −3.3 | 7.12E-12 | Immunosuppression, T-cell proliferation |
GPR153 | G protein-coupled receptor 153 | 0.8 | 7.8 | −2.9 | 1.82E-11 | Signalling |
ZNF497 | Zinc Finger Protein 497 | 0.7 | 8.4 | −3.1 | 5.25E-11 | Transcriptional regulation |
KRT77 | Keratin 77 | 0.1 | 9.6 | −5.3 | 7.34E-11 | Epithelial cell structure |
CENPF | Centromere Protein F | 4.1 | 20.0 | −2.1 | 9.29E-11 | Mitosis |
ZC2HC1A | Zinc Finger C2HC-Type Containing 1A | 2.1 | 10.9 | −2.2 | 9.29E-11 | Unknown |
IGKV1D-43 | Immunoglobulin Kappa Variable 1D-43 | 0.7 | 181.3 | −6.3 | 2.07E-10 | Antigen recognition |
ROBO1 | Roundabout Guidance Receptor 1 | 1.8 | 19.6 | −2.7 | 2.13E-10 | Mediation of cellular migration |
CRISPLD1 | Cysteine Rich Secretory Protein LCCL Domain Containing 1 | 0.2 | 3.0 | −3.7 | 2.32E-10 | Component of extracellular region |
LEPR | leptin receptor | 4.0 | 166.7 | −4.4 | 2.32E-10 | Regulation of fat metabolism |
GREB1 | growth regulation by estrogen in breast cancer 1 | 0.0 | 1.1 | −5.7 | 2.40E-10 | Estrogen-simulated cell proliferation |
CNTFR | ciliary neurotrophic factor receptor | 1.4 | 26.2 | −3.4 | 2.94E-10 | Interleukin signalling |
MIR5001 | MicroRNA 5001 | 1.6 | 13.1 | −2.6 | 2.97E-10 | Post-transcriptional regulation |
C14orf180 | Chromosome 14 Open Reading Frame 180 | 3.2 | 17.9 | −2.2 | 3.06E-10 | Plasma membrane component |
TGIF2 | TGFB Induced Factor Homeobox 2 | 1.1 | 13.3 | −3.2 | 4.25E-10 | Transcriptional repression |
KIF26B | kinesin family member 26B | 0.5 | 10.0 | −3.8 | 4.42E-10 | Cytoskeleton |
COL7A1 | collagen type VII alpha 1 chain | 0.1 | 5.7 | −5.1 | 4.44E-10 | Anchoring of basement membrane |
PTGER3 | Prostaglandin E Receptor 3 | 1.6 | 11.3 | −2.6 | 6.98E-10 | Receptor for prostaglandin E2; uterine contraction |
EDN3 | endothelin 3 | 0.0 | 11.4 | −6.4 | 7.19E-10 | Vasoconstriction |
CDC42EP3 | CDC42 Effector Protein 3 | 2.6 | 21.7 | −2.6 | 8.30E-10 | Actin cytoskeleton reorganisation |
KIF7 | Kinesin Family Member 7 | 0.4 | 3.8 | −2.7 | 1.45E-09 | Signalling; cilia-associated |
NCKAP5 | NCK Associated Protein 5 | 0.3 | 1.8 | −2.3 | 1.51E-09 | Unknown |
SALL4 | Spalt Like Transcription Factor 4 | 0.6 | 4.0 | −2.3 | 2.21E-09 | Transcription factor |
NYNRIN | NYN Domain And Retroviral Integrase Containing | 0.3 | 3.1 | −2.7 | 2.62E-09 | RNA binding |
IGKV3D-11 | Immunoglobulin Kappa Variable 3D-11 | 0.0 | 38.0 | −6.5 | 2.79E-09 | Antigen recognition |
FREM2 | FRAS1 related extracellular matrix protein 2 | 0.2 | 1.9 | −3.0 | 2.85E-09 | Basement membrane component; epidermal adhesion |
MEX3A | Mex-3 RNA Binding Family Member A | 0.7 | 7.6 | −2.9 | 2.93E-09 | RNA binding |
JCHAIN | Joining Chain Of Multimeric IgA And IgM | 4.6 | 456.8 | −5.3 | 5.05E-09 | Antigen recognition |
AKR1B1 | Aldo-keto reductase family 1, member B1 (aldose reductase) | 11.8 | 66.3 | −2.0 | 6.85E-09 | Sugar metabolism |
SMOC2 | SPARC related modular calcium binding 2 | 43.5 | 491.6 | −3.0 | 6.85E-09 | Cell matrix; cell proliferation; angiogenesis |
IGHV3-23 | Immunoglobulin Heavy Variable 3-23 | 0.9 | 54.0 | −4.9 | 8.50E-09 | Antigen recognition |
CASR | Calcium Sensing Receptor | 0.3 | 6.7 | −4.4 | 8.64E-09 | Intracellular signalling |
NINL | Ninein Like | 0.5 | 10.3 | −3.7 | 8.87E-09 | Mitosis |
NRG1 | Neuregulin 1 | 0.3 | 4.9 | −3.9 | 9.31E-09 | Cell signalling |
IGLV1-51 | Immunoglobulin Lambda Variable 1-51 | 0.0 | 82.6 | −6.4 | 1.08E-08 | Antigen recognition |
DACT1 | Dishevelled Binding Antagonist Of Beta Catenin 1 | 1.3 | 14.6 | −3.0 | 1.16E-08 | Intracellular signalling |
TCTN3 | Tectonic Family Member 3 | 3.0 | 16.6 | −2.0 | 1.26E-08 | Ciliogenesis |
IFIT5 | Interferon Induced Protein With Tetratricopeptide Repeats 5 | 1.9 | 16.1 | −2.6 | 1.27E-08 | RNA binding to viral RNAs |
LRRN3 | Leucine Rich Repeat Neuronal 3 | 0.3 | 5.1 | −3.3 | 1.80E-08 | Protein binding |
IGHA1 | Immunoglobulin Heavy Constant Alpha 1 | 17.0 | 1722.2 | −5.3 | 2.01E-08 | Antigen recognition |
