Table 3 KEGG pathways analysis using DAVID of genes upregulated during pregnancy.
Pathway accession | Pathway Term | Count | % | P-Value | Genes | Fold Enrichment | Benjamini-adjusted P-value | FDR |
|---|---|---|---|---|---|---|---|---|
mdo01100 | Metabolic pathways | 40 | 15.1 | 6.8E-07 | GALNT3, ALAD, SC5D, TALDO1, NAGS, ADPGK, HSD3B7, PAFAH2, EHHADH, ALG2, HMGCS1, GMPPB, ATP6V0C, CEPT1, PGP, ACSL1, DHCR7, HDC, ACAD8, IPMK, GALNT12, HSD17B7, MOCS2, PLA2G10, SLC33A1, PDXP, DPAGT1, IDO1, MGAT2, CYP27A1, MLYCD, SQLE, BCO1, AGXT2, PLA2G3, RDH16, AKR1D1, ALG12, PC, MDH1 | 2.2 | 1.03E-04 | 0.0 |
mdo00100 | Steroid biosynthesis | 4 | 1.5 | 2.9E-03 | SC5D, SQLE, DHCR7, HSD17B7 | 13.6 | 1.94E-01 | 3.4 |
mdo01130 | Biosynthesis of antibiotics | 10 | 3.8 | 4.0E-03 | SC5D, PGP, TALDO1, ADPGK, PAFAH2, SQLE, EHHADH, HMGCS1, HSD17B7, MDH1 | 3.2 | 1.82E-01 | 4.7 |
mdo00120 | Primary bile acid biosynthesis | 3 | 1.1 | 1.9E-02 | CYP27A1, HSD3B7, AKR1D1 | 13.8 | 5.13E-01 | 20.4 |
mdo00565 | Ether lipid metabolism | 4 | 1.5 | 2.6E-02 | CEPT1, PLA2G10, PAFAH2, PLA2G3 | 6.1 | 5.52E-01 | 27.3 |
mdo01200 | Carbon metabolism | 6 | 2.3 | 2.8E-02 | PGP, TALDO1, ADPGK, EHHADH, PC, MDH1 | 3.5 | 5.07E-01 | 28.5 |
mdo04142 | Lysosome | 6 | 2.3 | 3.5E-02 | ATP6V0C, NAGPA, MFSD8, AP3D1, CD164, AP4S1 | 3.3 | 5.34E-01 | 34.5 |
mdo04146 | Peroxisome | 5 | 1.9 | 3.8E-02 | ACSL1, MLYCD, EHHADH, GNPAT, SLC27A2 | 3.9 | 5.23E-01 | 37.4 |
mdo04141 | Protein processing in endoplasmic reticulum | 7 | 2.6 | 4.0E-02 | HYOU1, SYVN1, PDIA6, HSPA5, DNAJC3, LMAN1, SEC62 | 2.7 | 4.96E-01 | 38.7 |
mdo00510 | N-Glycan biosynthesis | 4 | 1.5 | 4.1E-02 | MGAT2, ALG2, DPAGT1, ALG12 | 5.2 | 4.69E-01 | 39.4 |
mdo03060 | Protein export | 3 | 1.1 | 5.2E-02 | SRPRA, HSPA5, SEC62 | 8.1 | 5.19E-01 | 47.1 |
mdo03320 | PPAR signaling pathway | 4 | 1.5 | 7.8E-02 | ACSL1, CYP27A1, EHHADH, SLC27A2 | 4.0 | 6.39E-01 | 62.0 |
mdo00410 | beta-Alanine metabolism | 3 | 1.1 | 8.2E-02 | MLYCD, EHHADH, CARNS1 | 6.2 | 6.28E-01 | 63.9 |
