Figure 3
The “Lejeune Machine”, representing human metabolism as a mechanical machine, with highlighting of metabolites (gears) with an altered concentration in DS plasma. The original Figure is a drawing by Jérôme Lejeune and it has been obtained thanks to courtesy of Mme Birthe Lejeune and used with her kind permission. The drawing has been modified here by the authors by means of coloring. Red = increased (at p < 0.05 and/or with a 1.3–1.7 DS/CTRL ratio); orange = increased, although at p ≥ 0.05 and not within the 1.3–1.7 ratio range; blue = decreased (at p < 0.05 and/or with a 0.58–0.76 DS/ CTRL ratio); green = decreased, although at p ≥ 0.05 and not within the 0.58–0.76 ratio range; yellow/violet = increased/decreased, according to literature data, respectively24,25,26,27,49. S-adenosylhomocysteine and S-adenosylmethionine plasma level were decreased according to Pogribna and Coll.27, and increased according to Obeid and Coll.26. The yellow gear above the “Krebs” gear represents cystathionine. Other explanations in the text.
