Table 2 Univariate statistical analysis of plasma samples.

From: Plasma and urinary metabolomic profiles of Down syndrome correlate with alteration of mitochondrial metabolism

Metabolites

DS (median)

CTRL (median)

DS/CTRL

p

pFDR

Cliff’s delta

2-Hydroxybutyrate

290.3

357.0

0.81

0.609

0.687

Negligible

3-Hydroxybutyrate

90.4

96.0

0.94

0.793

0.816

Negligible

Acetate

188.9

140.5

1.34*

0.02

0.063

Medium

Acetoacetate

77.4

44.7

1.73*

0.018

0.063

Medium

Acetone

92.8

72.5

1.28*

0.011

0.042

Medium

Alanine

1047.9

1071.4

0.98

0.713

0.78

Negligible

Citrate

111.7

95.4

1.17

0.086

0.167

Small

Creatine

146.7

78.7

1.86

0.001

0.008

Medium

Creatinine

127.9

147.0

0.87

0.101

0.178

Small

Formate

43.9

31.4

1.4*

0.002

0.01

Medium

Fumarate

2.9

2.1

1.39*

0.107

0.179

Small

Glucose

2390.5

2479.0

0.96

0.074

0.162

Small

Glutamate

93.7

77.9

1.2

0.053

0.124

Small

Glutamine

216.8

195.1

1.11

0.008

0.036

Medium

Glycerol

81.7

53.4

1.53*

0.008

0.036

Medium

Glycine

505.8

502.4

1.01

0.896

0.896

Negligible

Histidine

92.6

98.9

0.94

0.247

0.375

Small

Isoleucine

110.0

113.2

0.97

0.311

0.454

Small

Lactate

769.8

580.4

1.33*

0.096

0.177

Small

Lactate + Threonine

3912.7

2906.4

1.35*

0.05

0.124

Small

Leucine

357.3

345.9

1.03

0.528

0.661

Negligible

Lysine

56.2

67.7

0.83

0.048

0.124

Small

Mannose

19.9

20.2

0.98

0.609

0.687

Negligible

Methionine

203.0

177.4

1.14

0.083

0.167

Small

Phenylalanine

121.0

123.7

0.98

0.743

0.788

Negligible

Pyruvate

502.2

407.1

1.23

0.001

0.007

Large

Succinate

21.5

14.6

1.47*

0.0001

0.0008

Large

Threonine

34.9

39.1

0.89

0.183

0.291

Small

Tyrosine

120.4

135.7

0.89

0.021

0.063

Medium

Unk1

46.6

51.5

0.91

0.503

0.652

Negligible

Unk2

19.6

15.5

1.26

0.337

0.472

Negligible

Unk3

190.8

116.5

1.64*

0.00001

0.0002

Large

Valine

834.4

878.2

0.95

0.423

0.569

Negligible

  1. List of metabolites whose concentration levels (in arbitrary units) have been determined in all samples (DS, n = 41; CTRL, n = 25). The p-value (p) of the univariate Wilcoxon-Mann-Whitney test for each metabolite is reported together with the p-value calculated after false discovery rate correction (pFDR). The effect size, using the Cliff’s delta formulation, was also calculated to aid the identification of the meaningful signals giving an estimation of the magnitude of the separation between the different groups. Metabolites that show significant concentration differences in the two groups (p-value < 0.05) and/or show values in the interval next to 3:2 are reported in bold. *Values in the interval next to 3:2 (range 1.3–1.7).
Back to article page