Figure 4 | Scientific Reports

Figure 4

From: High dietary salt intake correlates with modulated Th17-Treg cell balance resulting in enhanced bone loss and impaired bone-microarchitecture in male mice

Figure 4

High dietary salt intake skews expression of osteoclastogenic factors. (A) Serum samples of mice were analyzed for secretion of various proinflammatory and anti-inflammatory cytokines by CBA (B) Average percentage (%) of CD4+RANKL+T cells in bone marrow (BM). (C) Average percentage (%) of total RANKL in bone marrow (BM). The results were evaluated by using ANOVA with subsequent comparisons by Student t test for paired or nonpaired data, as appropriate. Analysis was performed using Sigma plot software (Systat Software, Inc., Germany). Values are reported as mean ± SEM (n = 10) and similar results were obtained in three independent experiments. Statistical significance was defined as p ≤ 0.05 (*p ≤ 0.05, **p ≤ 0.01, ***p ≤ 0.001) with respect to low salt diet group.

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