Table 6 Association of body composition at 30 years with breastfeeding duration, according to FTO genotype (rs9939609).
From: Breastfeeding moderates FTO related adiposity: a birth cohort study with 30 years of follow-up
Adjusted regression coefficient (95% confidence interval)# | P-value - interaction | ||
|---|---|---|---|
Breastfeeding duration in months | |||
<1 | ≥1 | ||
Body mass index (kg/m 2 ) | |||
FTO genotype | p < 0.001** | P = 0.005* | 0.02 |
TT | Reference (0) | Reference (0) | |
TA | 1.14 (0.13; 2.15) | −0.01 (−0.55; 0.53) | |
AA | 2.58 (1.30; 3.87) | 1.05 (0.34; 1.75) | |
Prevalence ratio of overweight | |||
FTO genotype | P = 0.004** | P = 0.05** | 0.08 |
TT | Reference (1) | Reference (1) | |
TA | 1.17 (0.98; 1.40) | 1.02 (0.94; 1.11) | |
AA | 1.33 (1.09; 1.62) | 1.11 (1.01; 1.23) | |
Fat mass index (kg/m 2 ) | |||
FTO genotype | P = 0.009** | P = 0.08* | 0.05 |
TT | Reference (0) | Reference (0) | |
TA | 0.63 (−0.10; 1.36) | −0.16 (−0.54; 0.22) | |
AA | 1.25 (0.30; 2.19) | 0.38 (−0.12; 0.89) | |
Lean mass index (kg/m 2 ) | |||
FTO genotype | P = 0.02** | P = 0.008** | 0.41 |
TT | Reference (0) | Reference (0) | |
TA | 0.36 (0.04; 0.68) | 0.13 (−0.05; 0.31) | |
AA | 0.44 (0.02; 0.86) | 0.32 (0.09; 0.56) | |
Waist circumference (cm) | |||
FTO genotype | P < 0.001** | P = 0.005* | 0.01 |
TT | Reference (0) | Reference (0) | |
TA | 2.21(0.04; 4.37) | −0.32 (−1.48; 0.83) | |
AA | 5.65 (2.88; 8.41) | 2.04 (0.53; 3;55) | |
Visceral fat thickness (cm) | |||
FTO genotype | P = 0.01** | P = 0.07** | 0.13 |
TT | Reference (0) | Reference (0) | |
TA | 0.26 (−0.09; 0.61) | 0.03 (−0.14; 0.21) | |
AA | 0.57 (0.13; 1.02) | 0.23 (0.00; 0.46) | |
Subcutaneous abdominal fat thickness (cm) | |||
FTO genotype | P = 0.003** | P = 0.002* | 0.11 |
TT | Reference (0) | Reference (0) | |
TA | 0.10 (−0.10; 0.31) | −0.01 (−0.11; 0.10) | |
AA | 0.42 (0.16; 0.68) | 0.21 (0.08; 0.35) | |
