Table 7 Association of body composition at 30 years with breastfeeding duration, according to FTO genotype (rs9939609).
From: Breastfeeding moderates FTO related adiposity: a birth cohort study with 30 years of follow-up
Adjusted regression coefficient (95% confidence interval)# | P-value - interaction | ||||
|---|---|---|---|---|---|
Breastfeeding duration in months | |||||
<1 | 1–2.9 | 3–5.9 | ≥6 | ||
Body mass index (kg/m 2 ) | |||||
FTO genotype | p < 0.001** | p = 0.09* | p = 0.12** | P = 0.18* | 0.07 |
TT | Reference (0) | Reference (0) | Reference (0) | Reference (0) | |
TA | 1.14 (0.13; 2.15) | −0.11 (−1.01; 0.78) | 0.19 (−0.81; 1.20) | −0.13 (−1.05; 0.78) | |
AA | 2.58 (1.30; 3.87) | 1.06 (−0.09; 2.20) | 1.08 (−0.20; 2.37) | 0.98 (−0.27; 2.23) | |
Prevalence ratio of overweight | |||||
FTO genotype | P = 0.004** | P = 0.07** | P = 0.05** | P = 0.87* | 0.03 |
TT | Reference (1) | Reference (1) | Reference (1) | Reference (1) | |
TA | 1.17 (0.98; 1.40) | 1.02 (0.88; 1.19) | 1.06 (0.92; 1.23) | 0.97 (0.84; 1.11) | |
AA | 1.33 (1.09; 1.62) | 1.19 (1.01; 1.40) | 1.19 (1.01; 1.41) | 0.97 (0.81; 1.16) | |
Fat mass index (kg/m 2 ) | |||||
FTO genotype | P = 0.009** | P = 0.28* | P = 0.09* | P = 0.93* | 0.07 |
TT | Reference (0) | Reference (0) | Reference (0) | Reference (0) | |
TA | 0.63 (−0.10; 1.36) | −0.25 (−0.90; 0.40) | −0.17 (−0.88; 0.55) | −0.12 (−0.75; 0.51) | |
AA | 1.25 (0.30; 2.19) | 0.38 (−0.45; 1.22) | 0.77 (−0.14; 1.68) | −0.09 (−0.96; 0.78) | |
Lean mass index (kg/m 2 ) | |||||
FTO genotype | P = 0.02** | P = 0.14** | P = 0.03** | P = 0.19** | 0.54 |
TT | Reference (0) | Reference (0) | Reference (0) | Reference (0) | |
TA | 0.36 (0.04; 0.68) | 0.16 (−0.14; 0.47) | 0.23 (−0.11; 0.56) | 0.01 (−0.29; 0.31) | |
AA | 0.44 (0.02; 0.86) | 0.28 (-0.11; 0.68) | 0.36 (−0.06; 0.79) | 0.33 (−0.08; 0.75) | |
Waist circumference (cm) | |||||
FTO genotype | P < 0.001** | P = 0.10* | P = 0.11* | P = 0.26* | 0.04 |
TT | Reference (0) | Reference (0) | Reference (0) | Reference (0) | |
TA | 2.21(0.04; 4.37) | −0.57 (−2.51; 1.36) | -0.08 (−2.03; 2.19) | −0.53 (-2.50; 1.43) | |
AA | 5.65 (2.88; 8.41) | 1.94 (−0.53; 4.41) | 2.48 (−0.23; 5.18) | 1.59 (−1.07; 4.25) | |
Visceral fat thickness (cm) | |||||
FTO genotype | P = 0.01** | P = 0.13** | P = 0.38* | P = 0.11** | 0.29 |
TT | Reference (0) | Reference (0) | Reference (0) | Reference (0) | |
TA | 0.26 (−0.09; 0.61) | 0.11 (−0.20; 0.42) | −0.27 (−0.60; 0.05) | 0.15 (−0.13; 0.44) | |
AA | 0.57 (0.13; 1.02) | 0.32 (−0.08; 0.71) | −0.03 (−0.45; 0.39) | 0.29 (−0.09; 0.68) | |
Subcutaneous abdominal fat thickness (cm) | |||||
FTO genotype | P = 0.003** | P = 0.04* | P = 0.02** | P = 0.35* | 0.22 |
TT | Reference (0) | Reference (0) | Reference (0) | Reference (0) | |
TA | 0.10 (−0.10; 0.31) | −0.09 (−0.26; 0.08) | 0.09 (−0.11; 0.28) | 0.00 (−0.17; 0.17) | |
AA | 0.42 (0.16; 0.68) | 0.18 (−0.04; 0.40) | 0.31 (0.07; 0.56) | 0.15 (−0.07; 0.38) | |
