Figure 3
2D and 3D cultured UC-MSCs could migrate into the ischemic damaged liver after intraperitoneal injection. (a) The in vivo imaging showed that both 2D and 3D UC-MSCs could aggregate into the ischemia-damaged liver at 6 h after intraperitoneal injection by observing the fluorescent signal (red) from DiR labeled UC-MSCs. The fluorescence intensity of were not statistically different between 2D and 3D UC-MSCs. Data are presented as means ± SE (n = 3). (b) The migration of UC-MSCs into the liver was further confirmed by immunohistochemical staining (x400) of human nuclear antigen (arrows). Abbreviations: DiR, 1,1′-dioctadecyltetramethyl indotricarbocyanine Iodide; UC-MSCs, umbilical cord-derived mesenchymal stem cells.
