Table 2 General characteristics of the included studies.

From: Plasma homocysteine concentrations and risk of intracerebral hemorrhage: a systematic review and meta-analysis

First author

Year

Country

Detecting methods

Hemorrhagic

Controls

Ischemic

No. of male patients

tHcy, μmol/L Mean ± SD

Age, Years

No. of male patients

tHcy, μmol/L Mean±SD

Age, Years

No. of male patients

tHcy, μmol/L Mean±SD

Age, Years

Bokhari FA

2012

Pakistan

ELISA

4/9

23.73 ± 13.61

NR

NR/33

20.73 ± 8.59

NR

10/22

20.45 ± 9.47

NR

Hiroyasu I

2004

Japan

HPLC

17/38

10.4 ± 2.86

64.7

51/114

9.2 ± 3.1

64.4

60/98

9.8 ± 3.99

65.9

Fang X(+/−)

2005

Mongolia

HPLC

NR/12

15.6 ± 4.6

NR

NR/6

12.9 ± 5.3

NR

NR/18

18.4 ± 8.9

NR

Fang X(+/+)

2005

Mongolia

HPLC

NR/5

20 ± 6.4

NR

NR/2

15.7 ± 6.3

NR

NR/11

21.3 ± 1.8

NR

Li ZH

2003

China

HPLC

318/503

14.6 ± 1.3

58.2 ± 9.6

1052/1832

12.8 ± 3.47

59.6 ± 8.8

513/807

14.7 ± 8.6

61.3 ± 9.7

Araki A

1989

Japan

HPLC

13/20

9.6 ± 3.9

65.4 ± 9.7

30/45

7.3 ± 2.9

62.9 ± 10.8

30/45

13.1 ± 5.6

63.3 ± 10.9

Perini F

2005

Italy

HPLC

39/70

18.18 ± 14.08

69.5 ± 13.8

201/421

11.97 ± 6.61

56.6 ± 14.8

399/775

18.94 ± 13.65

71.6 ± 12.1

Fang X(−/−)

2005

Mongolia

HPLC

NR/3

20.5 ± 8.6

NR

NR/16

15.4 ± 4.2

NR

NR/13

18.9 ± 8.0

NR

Peng H

2000

China

HPLC

NR/7

18.77 ± 5.58

NR

26/31

11.46 ± 5.96

51.8

NR/32

18.72 ± 10.55

NR

  1. M male, n number, tHcy total homocysteine, NR not reported, ELISA enzyme-linked immunosorbent assay, HPLC high-performance liquid chromatography, +/+ homozygous methylenetetrahydrofolate reductase gene mutation, +/− heterozygous methylenetetrahydrofolate reductase gene mutation, −/− wild-type.