Figure 5
Deletion of Palb2 did not rescue the developmental defect in CKO mammary glands. (a) Whole mounts of mammary glands from 8-week virgin mice. Red dash line highlights the boundary of the ductal area. Images are representatives of at least 4 animals in each group. Scale bars = 1 mm. (b) Longitudinal quantification of ductal lengths at 6, 8, and 12-week time points. The numbers of animal used for each of the three time points (6, 8, and 12 wks) are: WT = 4, 4, and 5 mice, CKO = 3, 6, and 5 mice, PKO = 5, 4, and 4 mice, PKO/CKO = 4, 5, 4 mice. Error bars represent s.e.m. Student’s t-test was used for statistical analysis comparison between WT and CKO (in black), and between CKO and CKO/PKO (in red). **P < 0.01, ns: not significant. (c) Whole mounts of mammary glands from 16 to 20-week mice 1-day postpartum. Scale bar = 500 μm.
