Table 1 The sensitivity of individual and combinational examination of serum biomarkers in CRC patients.
Markers | Sensitivity | Specificity | |
|---|---|---|---|
Single Marker | CEA | 46.59% (130/279) | 80% (59/74) |
CA199 | 14.39% (41/279) | 89% (66/74) | |
CA724 | 44.80% (125/279) | 97% (72/74) | |
CA125 | 10.04% (28/279) | 99% (73/74) | |
SF | 10.39% (29/279) | 95% (70/74) | |
Two Markers Combination | CEA + CA199 | 49.46% (138/279) | 78% (58/74) |
CEA + CA724 | 60.93% (170/279) | 77% (57/74) | |
CEA + CA125 | 53.05% (148/279) | 78% (58/74) | |
CEA + SF | 52.69% (147/279) | 77% (57/74) | |
CA199 + CA724 | 52.33% (146/279) | 86% (64/74) | |
CA199 + CA125 | 21.86% (61/279) | 89% (66/74) | |
CA199 + SF | 21.51% (60/279) | 85% (63/74) | |
CA724 + CA125 | 51.25% (143/279) | 96% (71/74) | |
CA724 + SF | 51.97% (145/279) | 92% (68/74) | |
CA125 + SF | 18.64% (52/279) | 93% (69/74) | |
Three Markers Combination | CEA + CA199 + CA724 | 63.08% (176/279) | 76% (56/74) |
CEA + CA199 + CA125 | 54.12% (151/279) | 78% (58/74) | |
CEA + CA199 + SF | 53.41% (149/279) | 76% (56/74) | |
CEA + CA724 + CA125 | 65.59% (183/279) | 76% (56/74) | |
CEA + CA724 + SF | 64.87% (181/279) | 74% (55/74) | |
CEA + CA125 + SF | 57.71% (161/279) | 76% (56/74) | |
CA199 + CA724 + CA125 | 56.99% (159/279) | 86% (64/74) | |
CA199 + CA724 + SF | 55.56% (155/279) | 82% (61/74) | |
CA199 + CA125 + SF | 27.24% (76/279) | 85% (63/74) | |
CA724 + CA125 + SF | 56.99% (159/279) | 91% (67/74) | |
Four to Five Markers Combination | CEA + CA199 + CA724 + CA125 | 66.67% (186/279) | 76% (56/74) |
CEA + CA199 + CA724 + SF | 65.59% (183/279) | 73% (54/74) | |
CEA + CA199 + CA125 + SF | 56.63% (158/279) | 76% (56/74) | |
CEA + CA724 + CA125 + SF | 66.31% (185/279) | 73% (54/74) | |
CA199 + CA724 + CA15 + SF | 60.22% (168/279) | 82% (61/74) | |
CEA + CA199 + CA724 + CA125 + SF | 67.38% (188/279) | 73% (54/74) |
