Table 2 The relationship of biomarkers and clinicopathological parameters of CRC.

Clinicopathological parameters	Cases	CEA				CA199				CA724				CA125				SF
Clinicopathological parameters	Cases	Pos	Neg	p	Χ ²	Pos	Neg	p	Χ ²	Pos	Neg	p	Χ ²	Pos	Neg	p	Χ ²	Pos	Neg	p	Χ ²
Age
<60	106	46	60	0.402	0.703	14	92	0.583	0.302	62	44	0	12.951	8	98	0.279	1.173	14	92	0.228	1.453
≥60	173	84	89	0.402	0.703	27	146	0.583	0.302	63	110	0	12.951	20	153	0.279	1.173	15	158	0.228	1.453
Gender
Male	157	78	79	0.241	1.375	20	137	0.295	1.096	72	85	0.687	0.162	11	146	0.056	3.65	15	142	0.602	0.272
Female	122	52	70	0.241	1.375	21	101	0.295	1.096	53	69	0.687	0.162	17	105	0.056	3.65	14	108	0.602	0.272
Lymphatic metastasis
Yes	103	59	44	0.006	7.493	24	79	0.002	9.646	65	38	0	22.121	8	95	0.335	0.931	10	93	0.774	0.082
No	176	71	105	0.006	7.493	17	159	0.002	9.646	60	116	0	22.121	20	156	0.335	0.931	19	157	0.774	0.082
Vascular invasion
Yes	18	9	9	0.765	0.09	4	14	0.351	0.87	10	8	0.343	0.9	6	12	0	21.93	2^*	16	1	0.011
No	261	121	140	0.765	0.09	37	224	0.351	0.87	115	146	0.343	0.9	22	239	0	21.93	27	234	1	0.011
Nerve infiltration
Yes	15	12	3	0.008	7.109	0^*	15	0.138	2.731	7	8	0.881	0.022	5	10	0.01	9.53	3^*	12	0.195	1.57
No	264	118	146	0.008	7.109	41	223	0.138	2.731	118	146	0.881	0.022	23	241	0.01	9.53	26	238	0.195	1.57
Degree of differentiation
Poorly	35	18	17	0.401	1.828	11	24	0.007	10.004	7	28	0.006	10.35	4	31	0.029	7.097	2^*	33	0.619	0.959
Moderately	236	110	126			28	208			115	121			21	215			26	210
Highly	8	2^*	6			2^*	6			3^*	5			3^*	5			1^*	7
pTNM staging
Stage I	51	12	39	0	24.604	1	50	0	50.275	10	41	0	28.329	2^*	49	0.011	6.479	6	45	0.783	1.075
Stage II	117	51	66			12	105			49	68			9	108			14	103
Stage III	96	54	42			17	79			53	43			14	82			8	88
Stage IV	15	13	2			11	4			13	2			3*	12			1*	14

*Indicates that the theoretical frequency of the four-cell table is less than 5, and the statistical analysis was performed using Fisher exact probability method. Pos: Positive; Neg: Negative.

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