Figure 7 | Scientific Reports

Figure 7

From: Incorporation of a skeletal muscle-specific enhancer in the regulatory region of Igf1 upregulates IGF1 expression and induces skeletal muscle hypertrophy

Figure 7

Evaluation of the systemic effect of elevated IGF1 in skeletal muscle. (a) ELISA analysis of the total IGF1 levels in serum from two-month-old GM mice and WT littermates (n = 9–10 per group). (b) Determination of the weight of the heart from three-month-old GM mice and WT littermates (n = 7–13 per group). (c) No pathological changes were detected by H&E analysis of the longitudinal section of hearts from three-month old GM mice and WT littermates. (d) Comparison of the tibia lengths of three-month-old GM mice and WT littermates. (n = 8–15 per group). Bars depict mean values, and error bars represent SEM. NS, not significant. Statistical significances were analysed by Student’s t-test.

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