Table 2 Unadjusted and adjusted Cox proportional hazards models for major adverse cardiac events according to risk groups and its individual components.
Variables | No adjustment HR (95% CI) | P Value | Model 1&HR (95% CI) | P Value | Model 2¶ HR (95% CI) | P Value | Model 3ϕ HR (95% CI) | P Value | Model 4§ HR (95% CI) | P Value | Model 5£ HR (95%CI) | P Value |
---|---|---|---|---|---|---|---|---|---|---|---|---|
Risk group analysis* | ||||||||||||
Low-risk | 1.00 (Reference) | 1.00 (Reference) | 1.00 (Reference) | 1.00 (Reference) | 1.00 (Reference) | 1.00 (Reference) | ||||||
Intermediate-risk | 3.08 (2.10–4.53) | <0.001 | 3.00 (2.04–4.40) | <0.001 | 2.67 (1.53–3.36) | <0.001 | 2.77 (1.85–4.15) | <0.001 | 2.18 (1.48–3.20) | <0.001 | 2.65 (1.76–3.98) | <0.001 |
High-risk | 11.63 (7.85–17.23) | <0.001 | 10.96 (7.38–16.26) | <0.001 | 6.26 (4.12–9.53) | <0.001 | 10.21 (6.32–16.51) | <0.001 | 6.90 (4.60–10.34) | <0.001 | 8.15 (5.01–13.24) | <0.001 |
Risk stratification from low to high | 3.50 (2.90–4.23) | <0.001 | 3.40 (2.81–4.11) | <0.001 | 2.56 (2.09–3.15) | <0.001 | 3.27 (2.57–4.17) | <0.001 | 2.76 (2.26–3.37) | <0.001 | 2.89 (2.27–3.68) | <0.001 |
Categorical biomarker analysis | ||||||||||||
WBC ≥8.62 × 109/L | 3.35 (2.53–4.43) | <0.001 | 3.36 (2.54–4.44) | <0.001 | 2.17 (1.61–2.92) | <0.001 | 3.33 (2.35–4.74) | <0.001 | 2.17 (1.63–2.89) | <0.001 | 2.85 (2.00–4.06) | <0.001 |
Hemoglobin <128 g/L | 2.94 (2.20–3.94) | <0.001 | 2.62 (1.92–3.59) | <0.001 | 1.77 (1.27–2.48) | 0.001 | 1.69 (1.10–2.59) | 0.016 | 2.23 (1.65–3.00) | <0.001 | 1.58 (1.02–2.46) | 0.042 |
MPV ≥12.9 fL | 2.41 (1.85–3.16) | <0.001 | 2.45 (1.87–3.20) | <0.001 | 2.43 (1.85–3.21) | <0.001 | 3.56 (2.31–5.49) | <0.001 | 2.53 (1.94–3.31) | <0.001 | 2.92 (1.88–4.53) | <0.001 |
Continuous biomarkers analysis | ||||||||||||
WBC, per 1 × 109/L increment | 1.13 (1.11–1.17) | <0.001 | 1.14 (1.11–1.17) | <0.001 | 1.05 (1.01–1.08) | 0.011 | 1.80 (1.54–2.11) | <0.001 | 1.06 (1.03–1.09) | <0.001 | 1.45 (1.28–1.65) | <0.001 |
Hemoglobin, per g/L increment | 0.98 (0.97–0.98) | <0.001 | 0.98 (0.97–0.99) | <0.001 | 0.99 (0.98–1.00) | 0.002 | 0.97 (0.96–0.99) | 0.001 | 0.98 (0.98–0.99) | <0.001 | 0.98 (0.96–1.00) | 0.020 |
MPV, per fL increment | 1.29 (1.18–1.41) | <0.001 | 1.30 (1.19–1.42) | <0.001 | 1.30 (1.19–1.42) | <0.001 | 1.83 (1.50–2.22) | <0.001 | 1.30 (1.19–1.42) | <0.001 | 1.73 (1.41–2.11) | <0.001 |