Figure 7
From: Reverse Engineering the Intracellular Self-Assembly of a Functional Mechanopharmaceutical Device
Intracellular CFZ accumulation. Total intracellular CFZ accumulation in picomoles (pmoles) in RAW264.7 cells (~68,000 cells/well) when pre-incubated with (a) BafA1 and (b) NPPB and initial concentration of CFZ = 4, 6, and 8 μM at t = 4 hours. Significant inhibition of CFZ accumulation was measured at t = 4 hours when cells were exposed to BafA1. To the contrary, no such inhibition was measured when cells were exposed to NPPB at t = 4 hours. Data are the mean ± S.D. of six experiments. *p < 0.05, **p < 0.01, ***p < 0.001. Each data point was compared in a pair-wise independent Student t-test.
