Figure 1
From: araGWAB: Network-based boosting of genome-wide association studies in Arabidopsis thaliana
Overview of the network-based boosting of GWAS signals by araGWAB. First, araGWAB takes GWAS summary statistics (SNP P-values) (A) and then assigns them to genes by chromosomal proximity (B). The significance of the phenotype-association for each gene is based on the assigned P-value, which is overlaid on a co-functional network of Arabidopsis genes, AraNet (C). The significance of each gene is boosted by guilt-by-association, resulting in additional candidate genes (e.g., Gene D) for the phenotype (D).
