Figure 4
From: Murine hematopoietic stem cell reconstitution potential is maintained by osteopontin during aging
Aged OPN-deficient bone marrow cells display reduced reconstitution ability in a competitive transplantation setting. (A) Schematic of the competitive repopulation assay, which was performed to test the ability of aged OPN mutant stem cells to compete against WT HSCs. Analyses of the peripheral blood cells 8 weeks (B) and 16 weeks (C) after transplantation. (D) Further cell subtype analyses of the bone marrow compartment. Values are the mean ± SD, n = 9, *P < 0.05, **P < 0.01, ***P < 0.001.
