Figure 1 | Scientific Reports

Figure 1

From: The Urokinase Receptor Induces a Mesenchymal Gene Expression Signature in Glioblastoma Cells and Promotes Tumor Cell Survival in Neurospheres

Figure 1

uPAR expression correlates with patient survival in gliomas. (A) TCGA data were mined. The relative quantity (RQ) of PLAUR mRNA is shown for grade II, III, and IV gliomas (***p < 0.001; one way ANOVA with Bonferroni’s multiple comparison test). (B) Kaplan-Meier survival curves were generated from TCGA data, comparing grades II-IV glioma patients collectively. Cases were stratified to compare the 25% in which the tumors demonstrated the highest PLAUR mRNA expression levels with the 25% in which the tumors demonstrated the lowest PLAUR mRNA expression levels. Statistical significance was determined using the Log-rank test. (C) Kaplan-Meier patient survival curves were generated using TCGA RNA-Seq data and comparing glioblastoma cases in which PLAUR mRNA expression was above or below the median expression level. Cases in the top 5% for PLAUR mRNA expression also were evaluated. Statistical significance was determined by Log-rank test. (D) Kaplan-Meier survival curves were generated as described in panel C, but with GCIMP tumors omitted from the analysis.

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