Figure 5 | Scientific Reports

Figure 5

From: PREP1 tumor suppressor protects the late-replicating DNA by controlling its replication timing and symmetry

Figure 5

PREP1 DNA-binding sites landscape in HeLa cells. (A) A summary of the annotation of the 3,909 PREP1 peaks (p < 10−5) obtained by ChIP-seq: Promoter (±2.5 Kb from TSS), gene body, intergenic, and their overlaps with different histone marks. (B) Number of genes whose transcription is affected by PREP1 down-regulation: total, within LtoE contigs, within EtoL contigs, Lamin-bound, as indicated. The results are expressed as average of biological triplicate. Down and up indicate decrease (>40%), or increase (>2X) of the mRNA levels, respectively, in siPREP1- vs. siLuc-transfected cells.

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