Table 1 PREP1 down-regulation induces Late-to-Early (LtoE) and Early-to-Late (EtoL) DNA replication shifts in HeLa cells*.

From: PREP1 tumor suppressor protects the late-replicating DNA by controlling its replication timing and symmetry

 

250 Kb windows

Clustered contigs

Length of contigs (Mb)

Genome fraction

LtoE shifts

7,643

1,717

0.25–2.5

771 Mb (25.4%)

EtoL shifts

1,072

410

0.250–1.85

140 Mb (4.6%)

  1. *LtoE and EtoL S50 shifts are calculated for each 250 Kb sliding window as:
  2. Max S50 siPREP1 - Max S50 siLuc.
Back to article page