Figure 1 | Scientific Reports

Figure 1

From: Characterization of gene regulation and protein interaction networks for Matrin 3 encoding mutations linked to amyotrophic lateral sclerosis and myopathy

Figure 1

A graphic representation of the interactome for WT-MATR3 in human HEK293 cells. Proteomic mass spectrometry data from Supplemental Table S4 and the software program Cytoscape (version 3.5.1)42 were used to generate a graphic representation of MATR3 interaction. The intensity of shading of the oval containing the gene name is linked to the spectral counting data in Supplemental Table 4; the lighter the shading the higher the fold increase in spectral counts for a given protein relative to controls (untransfected cells; no expression of Avi-tagged MATR3). Proteins marked with an asterisk are interactors also identified by other studies (see Supplemental Table S4). The localization or function of the identified proteins was determined by three sources {www.uniprot.org} and43,44. Using quantification by label-free spectral counting, HNRNPM and numerous RNA processing factors including ADAR, PDBP3, SFRS14, and PTBP1 appear to be the strongest interactors with MATR3.

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