Figure 3
From: STAT3 regulates cytotoxicity of human CD57+ CD4+ T cells in blood and lymphoid follicles
CD57+ CD4+ T cells are not enriched with TFR cells. (A) Flow cytometric analysis of either CD25+ CD127− or CD25− CD127− CD4+ T cells for expression of CD57 and PD-1. (B) Summary of analysis in (A) (n = 4). (C) Representative analysis of CD4+ CD25+ CD127− T cells obtained from either blood or tonsil for FOXP3 and CD57 expression according to CD25+ or CD25− co-expression. (D) Summary of CD57+ cells within CD25+ or CD25− TFH (CXCR5hi PD-1hi) (n = 4). (E) Analysis of TFH and non-TFH PD-1+ cells for expression of CD25 and CD127. (F,G) Analysis and summary of proportion of IL-10 expression in CD57+ cells after gating on indicated regions in (E) (n = 3). *p < 0.05; **p < 0.01.
