Table 2 Spearman correlation analysis for molecule fragments ESP descriptors and antibody binding ability (expressed by IC₅₀ values).

Group	Method	S	S ⁺	S ⁻	P	I	A	Va	Va ⁺	Va ⁻	B
R₁	Spearman Correlation	−0.667	0.943**	−0.943**	0.943**	0.314	0.943**	0.314	0.943**	−0.2	0.841*
R₁	Sig. (2-tailed)	0.148	0.005	0.005	0.005	0.544	0.005	0.544	0.005	0.704	0.036
R₂	Spearman Correlation	0.143	−0.029	0.086	0.314	0.174	−0.029	−0.143	−0.086	0.086	0.600
R₂	Sig. (2-tailed)	0.787	0.9572	0.872	0.544	0.742	0.957	0.787	0.872	0.872	0.208
R₃	Spearman Correlation	0.257	−0.086	0.671	0.872	0.714	−0.257	0.754	0.257	0.872	0.621
R₃	Sig. (2-tailed)	0.623	0.872	0.215	0.0539	0.111	0.623	0.084	0.623	0.054	0.188

**Correlation is significant at 0.01 level (2-tailed). *Correlation is significant at 0.05 level (2-tailed).

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