Figure 1
From: Optimized peptide based inhibitors targeting the dihydrofolate reductase pathway in cancer
(a) Crystal structure of DHFR co-crystallised with Folic acid (orange). Pink dotted lines are H-bonds of folic acid with the various residues, (the distances are given in Å); (b) 2D diagram of the binding pose of folic acid in the active site of hDHFR.
